Problems associated with switch to
modafinil - a novel alerting agent in narcolepsy

Guilleminault C, Aftab FA, Karadeniz D, Philip P, Leger D
Stanford Sleep Disorders Clinic
and Research Center, CA 94605, USA.
Eur J Neurol 2000 Jul; 7(4):381-4


Modafinil is a novel medication recently approved for the treatment of narcolepsy and idiopathic hypersomnia. Commonly, patients had already been prescribed medications for their syndrome. This report outlines difficulties encountered in the clinical practice of switching patients to modafinil. Naive subjects accepted modafinil best. Subjects withdrawn from amphetamine had the most problems and failure to withdraw. Venlafaxine hydrochloride combined well with modafinil to control cataplectic attacks. Usage of a progressive withdrawal protocol may ease the difficulties observed.

Modafinil: review
Modafinil: structure
Modafinil and serotonin
Excessive daytime sleepiness
Modafinil as an antidepressant
Modafinil versus amphetamine
Modafinil and the hypothalamus