The stimulant effect of modafinil on wakefulness is not associated with an increase in anxiety in mice. A comparison with dexamphetamine
Simon P, Panissaud C, Costentin J
Unite de Neuropsychopharmacologie experimentale,
U.R.A. 1170 du C.N.R.S.,
Faculte de Medecine et Pharmacie de Rouen,
Saint Etienne du Rouvray, France.
Psychopharmacology (Berl) 1994 May; 114(4):597-600


Modafinil is a new drug used in the treatment of narcolepsy. Its administration in mice induced a dose-dependent increase in locomotor activity. The effects of modafinil were compared with those of dexamphetamine on three tests that assessed the anxiety level (drugs were used at doses which induced a roughly similar stimulation of locomotor activity). Dexamphetamine increased the latency of exploration of a white compartment, increased thigmotaxis in an open-field and decreased the time spent in the open arms of an elevated plus-maze. None of these responses was significantly modified by modafinil. We conclude that modafinil does not share the anxiogenic effects of dexamphetamine.

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